VU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour.
in vivo
VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1].
Animal Model:
CD-1 mice[1]
Dosage:
10 mg/kg (10% Tween 80 formulation)
Administration:
Intraperitoneal injection.
Result:
1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1].
