1268245-19-7

Name	PX 102
CAS	1268245-19-7
Molecular Formula	C29H22Cl3NO4
MDL Number	MFCD32204663
Molecular Weight	554.85
MOL File	1268245-19-7.mol

Synonyms

PX 102 CPD1220 Benzoic acid, 4-[2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]-

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Hazard Information

Uses

PX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy[1].

References

[1] Deuschle U, et al., FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012;7(10):e43044. DOI:10.1371/journal.pone.0043044

Supplier

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185 18149758185

Websitehttp://www.caerulumpharma.com

Jinan Yaoyan Pharmaceutical Co., Ltd.

Telephone

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30574/0_EN.htm

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Telephonemeitaochem@126.com

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31244/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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1089660-72-9 1268244-88-7

933799-50-9 946426-88-6

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