126333-28-6

SKF-107457 is a HIV protease type 1 inhibitor, and are hexapeptide substrate analogues with the scissile bond being replaced by a hydroxyethylene isostere.

SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research[1][2].

[1] Verkhivker GM. Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic analysis of hydrophobic mutations. Pac Symp Biocomput. 1996:638-52. PMID:9390264
[2] Fitzgerald P M D. HIV protease-ligand complexes: Current Opinion in Structural Biology 1993, 3: 868–874[J]. Current Opinion in Structural Biology, 1993, 3(6): 868-874.