1260635-77-5

Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor. Coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. coumarin-SAHA is used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes.

Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors.

ChEBI: Coumarin-SAHA is a member of coumarins.

HDAC8

325 nm/400 nm