THPP-4 is a phosphodiesterase 10A (PDE10A) inhibitor.
Uses
Phosphodiesterase 10-IN-2 (THPP-4) is an oral active phosphodiesterase 10A (PDE10A) inhibitor with the Ki of 4.5 nM. Phosphodiesterase 10-IN-2 can be used for study of schizophrenia[1].
References
[1] Raheem IT, et al. Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5903-8. DOI:10.1016/j.bmcl.2012.07.072
