ChemicalBook CAS DataBase List 1253573-53-3

1253573-53-3

Name	AMG 511
CAS	1253573-53-3
Molecular Formula	C22H28FN9O3S
Molecular Weight	517.58
MOL File	1253573-53-3.mol

Chemical Properties

solubility	Acetonitrile: Slightly soluble: 0.1-1 mg/ml DMSO: Sparingly soluble: 1-10 mg/ml
form	Solid
color	Light yellow to yellow

Hazard Information

Spectrum Detail

Supplier

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070 13770331960

Websitehttp://www.echemlin.cn

Sichuan Wei Keqi Biological Technology Co., Ltd.

Telephone028-81700200 18116577057

Websitehttps://www.weikeqi-biotech.com/

Shanghai YuanQi Biotechnology Co., Ltd.

Telephone+86-2332782371 +86-18120098618

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16784/0_EN.htm

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Changzhou Chenhong Biotechnology Co., Ltd.

Telephone+86-0519-85788828 +86-13775037613

Websitehttp://www.chemrenblock.com/

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

Energy Chemical

Telephone400-0056266

Websitehttp://www.energy-chemical.com

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

InvivoChem

Telephone 13549236410

Websitehttps://www.invivochem.cn/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Zhengzhou Converging Chemical Co. LTD

Telephone0371-53399770 18037166334

Websitehttps://www.chemicalbook.com/supplier/24218235/

Beijing Boorsen Biotechnology Co., Ltd

Telephone400-901-9800 18611424007

Websitehttp://www.bioss.com.cn/

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

Shanghai Anbida Biotechnology Co., Ltd.

Telephone021-61629020 18201956406

Websitehttps://www.ambeed.cn/

Shanghai Fengyong Biotechnology Co., Ltd.

Telephone021-10000000 13000000000

Websitehttps://www.abmole.cn

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Animal Model:	Female CD1 NU/NU mice, with U87 MG glioblastoma xenograft model^[1]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	Oral administration, daily, for 12 days
Result:	Inhibited tumor growth.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	1 mg/kg
Administration:	Oral administration (Pharmacokinetic Analysis)
Result:	Had a superior pharmacokinetic profile with low clearance (0.4 L/h/kg, 12% of liver blood flow), good oral bioavailability (F = 60%), and a commensurate high oral exposure (AUC = 5.0 μM·h).

1253573-53-3

Chemical Properties

Hazard Information

Uses

in vivo

IC 50

References

Spectrum Detail

Supplier

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