1252003-13-6

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor that has antitumor activity.

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1].

[1] Géraldy M, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443. DOI:10.1021/acs.jmedchem.8b01936