1246681-32-2

3’-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM. It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 μM, respectively. 3’-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) deficiency leading to progressive demyelination and neuromotor deficits. In mice lacking ASA, levels of 3’-sulfo galactosylsphingosine increase after one month of age followed by demyelination and neuromotor deficits. 3’-sulfo Galactosylsphingosine has been used as a standard for the quantification of 3’-sulfo galactosylsphingosine by LC-MS. [Matreya, LLC. Catalog No. 1904]

Lyso-sulfatide (bovine) ammonium, a derivative of the glycosphingolipid sulfatide, acts as an extracellular signal regulating the migration of a neural precursor cell line (B35 neuroblastoma cells) by rapidly promoting process retraction and cell rounding[1][2].

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[1] Mina Mirzaian, et al. Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography-tandem mass spectrometry. J Lipid Res. 2015 Apr;56(4):936-43. DOI:10.1194/jlr.M057232
[2] M Hans, et al. Lysosulfatide regulates the motility of a neural precursor cell line via calcium-mediated process collapse. Neurochem Res. 2009 Mar;34(3):508-17. DOI:10.1007/s11064-008-9813-7