Description
Sphinganine-d
7 (d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate .
1 Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.
2,3,4
References
1. Smith, E.R., and Merrill, A.H., Jr. Differential roles of de novo sphingolipid biosynthesis and turnover in the “Burst” of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture J. Biol. Chem. 270(32),18749-18758(1995).
2. Pruett, S.T., Bushnev, A., Hagedorn, K., et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols J. Lipid Res. 49(8),1621-1639(2008).
3. Shephard, G.S., van der Westhuizen, L., and Sewram, V. Biomarkers of exposure to fumonisin mycotoxins: A review Food Addit. Contam. 24(10),1196-1201(2007).
4. Yin, J., Miyazaki, K., Shaner, R.L., et al. Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markers FEBS Lett. 584(9),1872-1878(2010).
