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7α-Hydroxy-3-oxo-4-cholestenoic Acid is a bile acid precursor and is found in cerebrospinal fluid of Alzheimer’s patients and may be used in detection.

The levels of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) in cerebrospinal fluid are not correlated to neurodegeneration but may serve as a diagnostic marker to trace blood-brain barrier integrity.