1243259-19-9

LM11A-31 is a p75 neurotrophin receptor (p75^NTR) ligand that inhibits nerve growth factor (NGF) binding to p75^NTR-Fc (A₂ = 1,192 nM). It inhibits DNA damage in and promotes survival of hippocampal neuronal cultures in a p75^NTR- and concentration-dependent manner. LMA11A-31 also inhibits proNGF-induced cell death of mature oligodendrocytes. In vivo, LMA11A-31 (10-100 mg/kg) improves motor function and coordination in the weight-bearing open-field test and nonweight-bearing swim test and increases survival of oligodendrocytes in a mouse model of spinal contusion injury. It prevents and/or reverses atrophy of forebrain cholinergic neurites and cortical dystrophic neurites in Thy-1 hAPP^Lond/Swe and Tg2576 mice with mid- to late stage Alzheimer''s disease. It also reduces excessive alcohol self-administration in rats and decreases huntingtin (Htt) aggregate formation and striatal cholinergic degeneration in the R6/2 mouse model of Huntington''s disease.

(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide is used for the preparation of peptideamides for treatment of retroviral infection.

Store at -20°C

1) Massa?et al. (2006),?Small, Nonpeptide p75NTR Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death; J. Neurosci.?26?5288 2) Tep?et al., (2013),?Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury; J. Neurosci.?33?397 3) Shi?et al. (2013),?A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury; Stem Cells?31?2561 4) Simmons?et al.?(2014),?A small molecule p75(NTR) ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models with mid- to late-stage disease progression; PLoS One?9?e102136 5) Meeker?et al.?(2016),?Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis; Exp. Neurol.?275?Pt.1 182