ChemicalBook CAS DataBase List 1236667-40-5

1236667-40-5

Name	2(3H)-Benzoxazolone, 5-[[2-[(4-fluoro-3-methoxy-5-methylphenyl)amino]-5-methyl-4-pyrimidinyl]amino]-
CAS	1236667-40-5
Molecular Formula	C20H18FN5O3
Molecular Weight	395.39
MOL File	1236667-40-5.mol

Chemical Properties

density	1.405±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 62.5 mg/mL (158.07 mM; Need ultrasonic)
form	Solid
pka	8.94±0.70(Predicted)
color	Off-white to light yellow

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Animal Model:	C3H/HeJ induced by AA^[2]
Dosage:	10, 25, 50 mg/kg; single dose 0.5g/kg; daily; 12 weeks
Administration:	Oral
Result:	Showed that CD44+CD62L- CD8+ T effector/memory cells were significantly reduced in peripheral blood lymphoid organs of mice, the co-inhibitory receptor PD-1 was highly expressed on effector/memory CD8+ T cells, IFN-γ production was reduced, and γc cytokine regulated T cell exhaustion. Reduced inflammatory infiltrates and inflammatory markers, and the proportion of IFN-γ-producing CD8+ T cells was also significantly reduced.

1236667-40-5

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