3-ethylbicyclo[3.2.0]hept-3-en-6-one was synthesised from 4-Ethyl-3-hydroxyhept-6-enoic acid.
Preparation method: Intermediate (39.0 g, 226 mmol), acetic anhydride (195 mL), potassium acetate (51.4 g, 542 mmol) were added to the reaction flask, and the reaction was stirred at room temperature for 1 h, and the temperature was raised to 130 °C,The reaction was stirred for 4h, and the reaction was completed by GC monitoring. Add H2O (200mL), extract with EA (200mL*3), wash with 1N NaOH (100mL) and water (200mL), dry over anhydrous Na2SO4, filter, spin-dried to obtain the crude product of 3-ethylbicyclo[3.2.0]hept-3-en-6-one, and distilled under high vacuum to obtain 16g of 3-ethylbicyclo[3.2.0]hept-3-en-6-one , the appearance is colorless to light yellow oily liquid, the yield is 51.6%.
![3-ethylbicyclo[3.2.0]hept-3-en-6-one synthesis](/NewsImg/2023-11-24/6383643757173721588598819.png "3-ethylbicyclo[3.2.0]hept-3-en-6-one synthesis")
