ChemicalBook CAS DataBase List 123475-27-4

123475-27-4

Name	Beinaglutide
CAS	123475-27-4
Molecular Formula	C149H225N39O46
Molecular Weight	3298.67
MOL File	123475-27-4.mol

Chemical Properties

density	1.47±0.1 g/cm3(Predicted)
form	Solid
color	White to off-white
InChIKey	NGJOFQZEYQGZMB-BTCPGPLDNA-N

Hazard Information

Uses

Beinaglutide is a human GLP-1 polypeptide that shares almost 100% homology with human GLP-1 (7–36). Beinaglutide displays does-dependent effects in glycemic control, inhibiting food intake and gastric empty and promoting weight loss. Beinaglutide has the potential for the research of overweight/obesity and nonalcoholic steatohepatitis (NASH)[1][2].

in vivo

Beinaglutide (0.6, 1.2, 2.4 mg/kg; s.c.; three times per day for 7 consecutive days) shows the ability of glycemic contro, inhibits food intake and weight loss in mouse^[1].
Beinaglutide (150 μg/kg; s.c.; daily for 6 weeks) increases insulin sensitivity of adipocytes^[2].

Animal Model:	Wild-type male C57BL/6 mice and Male Lepob/Lepob (ob/ob) mice (ob/ob-NASH mouse model was induced by GAN diet)^[1]
Dosage:	0.6, 1.2, 2.4 mg/kg
Administration:	S.c.; three times per day for 7 consecutive days
Result:	Significantly reduced blood glucose with dosedependence in C57BL/6 and ob/ob mice, dose dependently inhibits food intake and gastric Emptying, and significantly reduced body weight, food intake with dose-dependence.

Animal Model:	Eight-week-old male C57BL/6 mice^[2]
Dosage:	150 μg/kg
Administration:	S.c.; daily for 6 weeks
Result:	Showed improved glucose tolerance and insulin sensitivity, decreased adipose tissue weight and adipocyte size and potentiated insulin sensitivity of adipocytes.

References

[1] Fang X, et al. Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model. Life Sci. 2021 Apr 1;270:118966. DOI:10.1016/j.lfs.2020.118966
[2] Zhang F, et al. Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice. iScience. 2021 Oct 30;24(12):103382. DOI:10.1016/j.isci.2021.103382

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