1233643-88-3

Name	Laninamivir Octanoate Hydrate
CAS	1233643-88-3
Molecular Formula	C21H38N4O9
Molecular Weight	490.548
MOL File	1233643-88-3.mol

Synonyms

Inavir Laninamivir Octanoate Monohydrate

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Hazard Information

Uses

Laninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses[1][2].

in vivo

Laninamivir octanoate (CS-8958; 95 μg/kg; intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection) treatment shows significantly life-prolonging effect in infected model^[1].

Animal Model:	Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34^[1]
Dosage:	0.2 μmol/kg (95 μg/kg)
Administration:	Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection
Result:	Showed life-prolonging effect in infected model.

References

[1] Makoto Yamashita, et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92. DOI:10.1128/AAC.00333-08
[2] Hideyuki Ikematsu, et al. Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza. Expert Rev Anti Infect Ther. 2011 Oct;9(10):851-7. DOI:10.1586/eri.11.112

Supplier

Hubei Yangxin Medical Technology Co., Ltd.

Telephone 15374522761

Websitehttps://www.standardpharm.org.cn/

Shanghai Yu Ben Biotechnology Co., Ltd.

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Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30592/0_EN.htm

TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

Hubei Yangxin Medical Technology Co., Ltd.

Telephone07143299675 13092790750

Websitehttps://www.yongstandards.com/

Shanxi Shengke Biotechnology Co., Ltd.

Telephone17633111049 17633111049

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