1227675-51-5

SCH 39166 is a dopamine D₁ receptor antagonist (K_i = 5 nM). It is selective for D₁ over D_2-4 receptors (K_is = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D₅ receptors (K_i = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED₅₀ = 0.84 mg/kg). It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake. SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.

SCH 39166 is a dopamine D1/D5 receptor antagonist used in the treatment of schizophrenia, cocaine addiction and obesity.

Desiccate at RT

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[2] P TERRY  J L K. A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behavior by the D1 agonist SKF38393.[J]. Psychopharmacology, 1994, 113 3-4: 328-333. DOI: 10.1007/bf02245205
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