Definition
ChEBI: Methylene blue is an organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor, an acid-base indicator, a fluorochrome, an antidepressant, a cardioprotective agent, an EC 3.1.1.8 (cholinesterase) inhibitor, a histological dye, an EC 4.6.1.2 (guanylate cyclase) inhibitor, an antioxidant, an antimicrobial agent, a neuroprotective agent, a physical tracer and an antimalarial. It contains a 3,7-bis(dimethylamino)phenothiazin-5-ium.
Preparation
N1,N1-dimethylbenzene-1,4-diamine in Sodium thiosulfate (had better have with Aluminium sulfate) exist, the Dichromate treatment into sulfur generation sulfonic acid (2 – amino – 5 – dimethylaminobenzene thiosulfate), this product then through Dichromate and N,N-dimethylaniline processing, Into indamine – thio acid, then use Dichromate and Copper sulfate monohydrate (or MnO2) cyclization and oxidation, and finally to Zinc chloride double salt out (2C116H18N3SC1,ZnC1.H2O).
