1223-36-5

Clofexamide ,CNRS

In 1 L of water there is dissolved 116.0 g (1 mole) of N,Ndiethylethylenediamine and, under vigorous stirring at a temperature maintained below 50°C, there is added 205.0 g (1 mole) of the chloride of pchlorphenoxyacetic acid. The solution becomes rapidly homogeneous; the formation of the basic amide hydrochloride is rapidly completed by further stirring the reaction mixture for 2 h at about 20°C. Then an excess of soda lye is added and the basic amide formed is extracted by ether. The ethereal solution is dried on anhydrous sodium sulfate and ether is distilled after that the residue is dried. So 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl) acetamide is obtained.

Antidepressant, Analgesic, Antiinflammatory, Local anesthetic