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PS315 is an allosteric atypical protein kinase C (aPKC) inhibitor that acts by binding to the PIF-pocket.

PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity[1].

PKCζ: 10 μM (IC₅₀); PKCη: 30 μM (IC₅₀)

[1] Zhang H, et al. Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound. Chem Biol. 2014 Jun 19;21(6):754-65. DOI:10.1016/j.chembiol.2014.04.007