122191-40-6

Name	CASPASE-1
CAS	122191-40-6
MDL Number	MFCD02677921

Synonyms

ICE CASP-1 IL-1BC CASPASE-1 ICE 1B HUMAN P45) USP/EP/BP CASPASE 1 HUMAN IL-1 β converting enzyme IL-1BETA CONVERTING ENZYME Interleukin-1β-Converting Enzyme INTERLEUKIN-1BETA CONVERTING ENZYME CASPASE-1 HUMAN, RECOMBINANT, ACTIVE CASPASE-1, HUMAN, RECOMBINANT, E COLI INTERLEUKIN-1B-CONVERTING ENZYME HUMAN ICE, Interleukin-1β-Converting Enzyme CASPASE-1 PROTEIN, RECOMBINANT HUMAN ACTIVE Anti-CASP1, C-Terminal antibody produced in rabbit Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit Anti-CASP1 (p20, Cleaved-Asn120) antibody produced in rabbit

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Chemical Properties

storage temp.	−70°C
form	powder
biological source	rabbit
Specific Activity	≥5000units/mg protein

Safety Data

WGK Germany

Hazard Information

Uses

Caspase 1 human has been used in in vitro cleavage assay with Rab interacting lysosomal protein (RILP) and in the cleavage of caspases-3/7 in human monocytic?cells (THP1).

General Description

Caspase 1, also called interleukin (IL)-1-converting enzyme, is mapped to human 11q22.3. It belongs to the aspartate-specific cysteine proteases family and is primarily synthesized as procaspase-1 zymogen, which later become catalytically active post autoproteolysis. The enzymatically active caspase-1 comprises two p20/p10 heterodimer making it a tetramer.

Biochem/physiol Actions

Caspase 1 catalyzes the conversion of pro-inflammatory cytokine, pro-interleukin (IL)-1β to its active form. It has broad substrate specificity and is an apoptosis regulator. Caspase-1 is indirectly implicated in the pathology of cryopyrin-associated periodic syndrome (CAPS). It is a multiple inflammasome-associated protein associated with multiple sclerosis (MS) lesions and is a prime target for inhibitor screening.

Supplier

Dideu Industries Group Limited

Telephone+86-29-89586680 +86-15129568250

Websitehttps://www.dideu.com

Shanghai Universal Biotech Co.,Ltd

Telephone 13774214275

Websitehttps://www.univ-bio.com/

Shanghai Yaji Biological Technology Co., Ltd.

Telephone021-34661275 15301693058

Websitehttp://www.yajimall.com/

Kamiya Biomedical Company

Telephone1-+1 206-575-8068 1206-575-8068

Websitehttp://www.kamiyabiomedical.com

Enzo Biochem Inc

TelephoneEnzo Biochem Inc. 13797054060

Websitehttp://www.enzo.com

Merck KGaA

Telephone21-20338288

Websitehttp://www.sigmaaldrich.cn

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