1217449-28-9

Formyl-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 (Formyl-[D-Trp6]-LH-RH Fragment 2-10) is a peptide from GnRH (gonadotropin-releasing hormone) agonisttriptorelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2)which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelinis crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropinsluteinizing hormone (LH) and follicle-stimulating hormone (FSH)from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Application of triptorelin suppresses premature LH surge in IVF (in vitro fertilization). Additionallytriptorelin-mediated o