1217338-97-0

Name	BMS-929075
CAS	1217338-97-0
Molecular Formula	C31H24F2N4O3
MDL Number	MFCD31556637
Molecular Weight	538.54
MOL File	1217338-97-0.mol

Synonyms

BMS-929075 BMS-929075, 10 mM in DMSO 4-Fluoro-2-(4-fluorophenyl)-n-methyl-5-(2-methyl-5-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)benzofuran-3-carboxamide 3-Benzofurancarboxamide, 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-[2-methyl-5-[[[1-(2-pyrimidinyl)cyclopropyl]amino]carbonyl]phenyl]-

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Chemical Properties

Boiling point	725.5±60.0 °C(Predicted)
density	1.41±0.1 g/cm3(Predicted)
pka	12.76±0.20(Predicted)

Hazard Information

Uses

BMS-929075 is a potent and orally active HCV NS5B replicase palm site allosteric inhibitor. BMS-929075 shows high oral bioavailability. BMS-929075 shows cytotoxicity[1].

in vivo

BMS-929075 (compound 37) (2 mg/kg for i.v.; 6 mg/kg for p.o.) shows good pharmacokinetic parameters with oral bioavailability of 48% in rats^[1].
Pharmacokinetic Parameters of BMS-929075 in Male Sprague-Dawley rats^[1].

	IV			PO
species	Cl (mL/min/kg)	IV t_1/2(hr)	V_ss(L/kg)	C_max(μM)	T_max(hr)	AUC (μM h)	C6 liver (μM)	C24 liver (μM)	C24 liver/plasma (μM)	F% (mL/min/kg)
rat	1.7	4.7	0.7	7.5	4	54.5	15.1	1.12	1.6	48

Rats, 2 mg/kg i.v.; 6 mg/kg p.o.^[1].

References

[1] Yeung KS, et al. Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J Med Chem. 2017 May 25;60(10):4369-4385. DOI:10.1021/acs.jmedchem.7b00328

Spectrum Detail

BMS-929075(1217338-97-0)¹HNMR

Supplier

Career Henan Chemica Co

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Websitehttps://www.coreychem.com/

Shanghai Yifei Biotechnology Co. , Ltd.

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RD International Technology Co., Limited

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TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

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Websitehttps://www.amole.com.cn/

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