1216897-16-3

ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential[1].

[1] Cohen A, et al. From the Gla domain to a novel small-molecule detector of apoptosis. Cell Res. 2009 May;19(5):625-37. DOI:10.1038/cr.2009.17