1214726-89-2

AS2521780 is a potent and selective PKCθ inhibitor.

AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM.

PKCθ: 0.48 nM (IC₅₀); PKCε: 18 nM (IC₅₀); PKCα: 160 nM (IC₅₀); PKCδ: 160 nM (IC₅₀)

Store at -20°C

[1] Fukahori H, et al. Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity. Eur J Pharmacol. 2014 Dec 15;745:217-22. DOI:10.1016/j.ejphar.2014.10.045