120533-76-8

BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable.

Diethyl 1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a cell-permeable and potent SIRT activator that induces cell cycle arrest. SIRT modulators have therapeutic potential the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases.

ChEBI: 4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine.

A mixture of benzaldehyde (0.05 mol), ethyl propargylate (0.10 mol), benzylamine (0.05 mol) and 5.0 mL of acetic acid was heated in a steam bath for 25 min [16,17]. After completion of the reaction, the crude product was purified by crystallization with a solvent mixture of methanol and water (4:1, v/v) followed by recrystallization with a solvent mixture of acetone and hexane (1:1, v/v) to give diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate.

Store at -20°C

1) Mai et al. (2009), Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors; J. Med.Chem.,52 5496