Urease-IN-16 (compound 4e) is a urease inhibitor, with an IC50 value of 132 μmol/L. Urease-IN-16 can coordinate with the nickel atom through the oxygen atoms of carbonyl or boronic acid groups. Urease-IN-16 shows great potential as an additive in the development of efficient fertilizers and medical applications[1].
References
[1] Morais Costa NE, et al. Synthesis and anti-ureolitic activity of Biginelli adducts derived from formylphenyl boronic acids. Bioorg Chem. 2024 Nov;152:107735. DOI:10.1016/j.bioorg.2024.107735
