120243-02-9

Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC₅₀ value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/ml.

Myxochelin A is a potent inhibitor of human 5-lipoxygenase (5-LO). Studies show that Myxochelin A is a natural product that may possess potent antitumor activity at non-cytotoxic concentrations.

[1] B KUNZE. Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties.[J]. Journal of Antibiotics, 1989, 42 1: 14-17. DOI: 10.7164/antibiotics.42.14
[2] SEBASTIAN SCHIEFERDECKER. Myxochelins Target Human 5-Lipoxygenase[J]. Journal of Natural Products , 2015, 78 2: 335-338. DOI: 10.1021/np500909b
[3] SATOSHI MIYANAGA. Absolute Configuration and Antitumor Activity of Myxochelin A Produced by Nonomuraea pusilla TP-A0861?[J]. Journal of Antibiotics, 2006, 59 11: 698-703. DOI: 10.1038/ja.2006.93