119413-55-7

Elgodipine (IQB-875 free base) is an orally active dihydropyridine calcium antagonist and an antianginal compound. Elgodipine inhibits both T- and L-type calcium channels (IC50: 32 and 2.3 nM). Elgodipine lowers systemic vascular resistance and improves systolic cardiac function[1][2][3].

T-type calcium channel: 32 nM (IC₅₀); L-type calcium channel: 2.3 nM (IC₅₀)

[1] Kuhn A, et al. Hemodynamic and antiischemic effects of intravenous elgodipine, a new dihydropyridine calcium channel blocker, in patients with chronic stable angina. Cardiovasc Drugs Ther. 1995 Aug;9(4):595-600. DOI:10.1007/BF00878092
[2] Lepretre N, et al. Electrophysiological and radioligand binding studies of elgodipine and derivatives in portal vein myocytes. J Pharmacol Exp Ther. 1994 Dec;271(3):1209-15. PMID:7996428
[3] Acharya DU, et al. Anti-ischaemic and haemodynamic effects of elgodipine, a potent new generation calcium antagonist, in chronic stable angina. Eur Heart J. 1994 May;15(5):665-71. DOI:10.1093/oxfordjournals.eurheartj.a060565