118675-83-5

DDPO is a folypolyglutamate synthetase antagonist.

DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 μM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 μM[1].

[1] Rosowsky A, et al., Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.