1186195-56-1

BU226 hydrochloride is a selective imidazoline 2 (I2) receptors ligand with an Ki of 1.4 nM for I2 and an IC50 of 534.5 nM for I1. BU226 hydrochloride can be used for researching antidepressant[1].

A high affinity ligand for I 2 imidazoline sites (K i = 2.7 nM) with very high selectivity (> 2000-fold) over α 2 -adrenoceptors (K i = 6700 nM).

[1] Hudson AL, et al. Novel selective compounds for the investigation of imidazoline receptors. Ann N Y Acad Sci. 1999 Jun 21;881:81-91. DOI:10.1111/j.1749-6632.1999.tb09344.x