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L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.

L-4-Oxalysine hydrochloride is a natural substance isolated from the culture medium of Streptomyces in China and has anticancer activity.

L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor.

L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma.

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[1] Dai ZQ, et al. Effect of L-4-oxalysine on ultrastructures of liver cells in mice. Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):336-40. PMID:1807083
[2] Wang XW, et al. Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein. Eur J Pharmacol. 1998 Jun 12;351(1):105-11. DOI:10.1016/s0014-2999(98)00277-5