117423-74-2

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT₁ receptor antagonist. It inhibits the specific binding of radiolabeled-LTB₄ to isolated human neutrophils with an IC₅₀ value of 13.2 nM. LY223982 inhibits the leukotriene B₄ (LTB₄)-induced aggregation of guinea pig and human neutrophils with IC₅₀ values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB₄ to human BLT₁ or BLT₂ expressed in CHO cells.

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.

Store at -20°C