ChemicalBook CAS DataBase List 117354-64-0

117354-64-0

Name	2-HYDROXYSACLOFEN
CAS	117354-64-0
Molecular Formula	C9H12ClNO4S
MDL Number	MFCD00069282
Molecular Weight	265.71
MOL File	117354-64-0.mol

Synonyms

2-Oh-saclofen HYDROXYSACLOFEN 2-HYDROXYSACLOFEN 2-Hydroxysaclofen solid 2-HYDROXYSACLOFEN, >99% 2-Hydroxysaclofen >=98% (TLC), solid 2-HYDROXYSACLOFEN ISO 9001：2015 REACH 2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA 3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf 3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PRO PANESULFON 3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANE-SULFONIC ACID 3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonicaci 3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid 3-Amino-2-hydroxy-2-(4-chlorophenyl)propane-1-sulfonic acid (+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYLSULFONIC ACID (RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYL-SULFONIC ACID (RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANESULPHONIC ACID (+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PROPANESULFONIC ACID Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy- beta-(Aminomethyl)-4-chloro-beta-hydroxybenzeneethanesulfonic acid Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy-

Chemical Properties

Melting point	267-269 °C
RTECS	DA0359200
storage temp.	2-8°C
solubility	H₂O: 1 mg/mL
form	solid
color	white
Water Solubility	Soluble in water at 1mg/ml. Also soluble in DMSO, 0.1M HCl and methanol

Safety Data

Hazard Codes	C
Risk Statements	34 less more
Safety Statements	26-27-36/37/39-45 less more
RIDADR	UN 1759 8/PG 3
WGK Germany	3
HazardClass	8

Hazard Information

Uses

2-Hydroxysaclofen is a GABA-B receptor antagonist in the ventral tegmental area and may play a role in the mechanisms of cocaine usage. Affects specific acute nicotine responses in mice, abolishing hypolocomotion and increasing antinociception.

Definition

ChEBI:3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid is an organochlorine compound.

Biological Activity

Selective antagonist at GABA B receptors.

in vivo

2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine^[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue^[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat^[3].

Animal Model:	Male Swiss Webster mice (22-24 g; treated with 3 mg/kg nicotine)^[1]
Dosage:	0.25, 0.5 and 1 mg/kg
Administration:	IP; single dosage; after 10 or 45 min of nicotine administration
Result:	Abolished nicotine hypolocomotor effects at 1 mg/kg, and increased the antinociceptive effects of nicotine at 1 mg/kg.

Animal Model:	Male Wistar rats^[2]
Dosage:	0.3, 1 and 3 mg/kg
Administration:	IP; single dosage
Result:	Reduced the effects of Baclofen on d-amphetamine-induced discriminative cue.

Animal Model:	Female Wistar rats (8 weeks)^[3]
Dosage:	0, 20, 50 or 100 μg/2 μL
Administration:	ICV; single dosage
Result:	Produced a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat with a dose-dependent manner, and the peak LH values were observed 10 min after the injection. The effect was dose-dependent, as 0 or 20 μg of the antagonist was ineffective while a pronounced effect was observed after the injection of 50 or 100 μg.

storage

Store at RT

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