ChemicalBook CAS DataBase List 117354-64-0

117354-64-0

Name	2-HYDROXYSACLOFEN
CAS	117354-64-0
Molecular Formula	C9H12ClNO4S
MDL Number	MFCD00069282
Molecular Weight	265.71
MOL File	117354-64-0.mol

Synonyms

2-Oh-saclofen HYDROXYSACLOFEN 2-HYDROXYSACLOFEN 2-Hydroxysaclofen solid 2-HYDROXYSACLOFEN, >99% 2-Hydroxysaclofen >=98% (TLC), solid 2-HYDROXYSACLOFEN ISO 9001：2015 REACH 2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA 3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf 3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PRO PANESULFON 3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANE-SULFONIC ACID 3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonicaci 3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid 3-Amino-2-hydroxy-2-(4-chlorophenyl)propane-1-sulfonic acid (+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYLSULFONIC ACID (RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYL-SULFONIC ACID (RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANESULPHONIC ACID (+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PROPANESULFONIC ACID Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy- beta-(Aminomethyl)-4-chloro-beta-hydroxybenzeneethanesulfonic acid Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy-

Chemical Properties

Melting point	267-269 °C
RTECS	DA0359200
storage temp.	2-8°C
solubility	H₂O: 1 mg/mL
form	solid
color	white
Water Solubility	Soluble in water at 1mg/ml. Also soluble in DMSO, 0.1M HCl and methanol

Safety Data

Hazard Codes	C
Risk Statements	34 less more
Safety Statements	26-27-36/37/39-45 less more
RIDADR	UN 1759 8/PG 3
WGK Germany	3
HazardClass	8

Hazard Information

Uses

2-Hydroxysaclofen is a GABA-B receptor antagonist in the ventral tegmental area and may play a role in the mechanisms of cocaine usage. Affects specific acute nicotine responses in mice, abolishing hypolocomotion and increasing antinociception.

Definition

ChEBI:3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid is an organochlorine compound.

Biological Activity

Selective antagonist at GABA B receptors.

in vivo

2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine^[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue^[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat^[3].

Animal Model:	Male Swiss Webster mice (22-24 g; treated with 3 mg/kg nicotine)^[1]
Dosage:	0.25, 0.5 and 1 mg/kg
Administration:	IP; single dosage; after 10 or 45 min of nicotine administration
Result:	Abolished nicotine hypolocomotor effects at 1 mg/kg, and increased the antinociceptive effects of nicotine at 1 mg/kg.

Animal Model:	Male Wistar rats^[2]
Dosage:	0.3, 1 and 3 mg/kg
Administration:	IP; single dosage
Result:	Reduced the effects of Baclofen on d-amphetamine-induced discriminative cue.

Animal Model:	Female Wistar rats (8 weeks)^[3]
Dosage:	0, 20, 50 or 100 μg/2 μL
Administration:	ICV; single dosage
Result:	Produced a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat with a dose-dependent manner, and the peak LH values were observed 10 min after the injection. The effect was dose-dependent, as 0 or 20 μg of the antagonist was ineffective while a pronounced effect was observed after the injection of 50 or 100 μg.

storage

Store at RT

Supplier

J & K SCIENTIFIC LTD.

Telephone 18210857532

Websitehttps://www.jkchemical.com

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

Dideu Industries Group Limited

Telephone+86-29-89586680 +86-15129568250

Websitehttps://www.dideu.com

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

MedBioPharmaceutical Technology Inc

Telephone021-69568360 18916172912

Websitehttp://www.med-bio.cn/

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Telephone024-024-024-88590548 18341751992

Website

Wuhan Jingkangen Biomedical Technology Co., Ltd

Telephone13720134139 086-15871494362 13720134139

Websitehttps://www.jknbiochem.com

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Telephone029-02961856358 15829236573

Website

Shaanxi Gulliver Biotechnology Research Co., Ltd

Telephone0917-7795337 18409274651

Website

R&D Systems, Inc

Telephone18003437475 18003437475

Websitehttp://www.rndsystems.com

Merck KGaA

Telephone21-20338288

Websitehttp://www.sigmaaldrich.cn

Adooq Bioscience LLC

Telephone400-025-6535

Websitehttp://www.adooq.cn

Santa Cruz Biotechnology Inc

Telephone 60936350

Websitehttp://www.scbt.com

DAYANG CHEM (HANGZHOU) CO.,LTD

Telephone+86-88938639 +86-17705817739

Websitewww.dycnchem.com

Hangzhou MolCore BioPharmatech Co.,Ltd.

Telephone+86-057181025280; +8617767106207

Websitehttps://www.molcore.com/

1of4

Related Products

Send Inquriy