1173022-16-6

The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC₅₀ = 0.36 μM). It inhibits the related CCR1 receptor with an IC₅₀ value of 17.8 μM and inhibits adrenergic α_1a, α_1d, and 5HT_1A receptors with IC₅₀ values of 0.13, 0.32, and 47 μM, respectively. RS 102895 prevents chemotaxis of THP-1 cells (IC₅₀ = 1.7 μM) when MCP-1 is presented as a chemoattractant.

RS 102895 Hydrochloride is used as a leukocyte infiltrate marker for rosacea diagnosis.

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