1172089-00-7

M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].

[1] Runesson J, Saar I, Lundstr?m L, J?rv J, Langel U. A novel GalR2-specific peptide agonist. Neuropeptides. 2009;43(3):187-192. DOI:10.1016/j.npep.2009.04.004