1169630-40-3

Ste-Glu-AEEA-AEEA-OSU (CAS 1169630-40-3, 95%~99% purity) is a key fatty acid side-chain intermediate used in the synthesis of the GLP-1R agonist semaglutide. Attaching this intermediate to the peptide backbone of the peptide drug semaglutide can significantly prolong the drug’s half-life and improve patient compliance.

Ste-Glu-AEEA-AEEA-OSU is an intermediate of semaglutide, a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy.

Both Ste-Glu-AEEA-AEEA-OSU and Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH (1662688-20-1) are key side chains in the synthesis of the peptide drug semaglutide, but they serve different functions. Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH is an integrated side-chain intermediate; whereas Ste-Glu-AEEA-AEEA-OSU is a modified fragment in which the terminal carboxyl group has already been activated to form an N-hydroxysuccinimide ester (NHS/OSU active ester). Researchers can use it either to directly modify pre-synthesised main-chain peptides in solution, or to carry out bulk modification on the resin during the final stage of solid-phase synthesis (SPPS).