Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme[1][2].
Definition
ChEBI: Sampangine is a copyrine alkaloid with formula C15H8N2O, extracted from several plants including the stem bark of Cananga odorata. It is a heme biosynthesis inhibitor and exhibits antifungal and anticancer properties. It has a role as a plant metabolite and an antifungal agent. It is an alkaloid and an organic heterotetracyclic compound.
References
[1] Pérez EG, et al. Alkaloids from the genus Duguetia. Alkaloids Chem Biol. 2010;68:83-156. DOI:10.1016/s1099-4831(10)06803-3 [2] Huang Z, et al. Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryot Cell. 2011 Nov;10(11):1536-44. DOI:10.1128/EC.05170-11
