1158098-73-7

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

3-Oxetanone (0.5 g, 7 mmol) and tert-butylsulfinamide (0.9 g, 7 mmol) were dissolved in ethanol (30 mL), titanium tetraisopropoxide (2 g, 7 mmol) was added, and the reaction was stirred for 8 hours at 80 °C. After the reaction was completed, 1N sodium hydroxide solution (10 mL) was added and stirring was continued for 2 hours at room temperature. The reaction mixture was concentrated to dryness and the resulting crude product was purified by silica gel column chromatography to give the final target product 3-[(tert-butylsulfinylidene)imino]oxetane (0.6 g, 76% yield) in white solid form.

[1] Organic Letters, 2011, vol. 13, # 15, p. 3912 - 3915
[2] Patent: CN108341814, 2018, A. Location in patent: Paragraph 0217-0218; 0220-0222
[3] Patent: US2012/108574, 2012, A1. Location in patent: Page/Page column 115
[4] Patent: EP3342765, 2018, A1. Location in patent: Paragraph 0231
[5] Patent: WO2012/13643, 2012, A1. Location in patent: Page/Page column 64