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Step i: 6-methoxy-7-nitro-1-indanone (10.0 g, 48.3 mmol) was dissolved in acetic acid (150 mL) at room temperature, followed by the addition of iron powder (10.8 g, 193 mmol). The reaction mixture was heated to 70 °C and stirred for 2 hours. After completion of the reaction, the mixture was cooled and filtered. The filtrate was concentrated under vacuum and the residue was diluted with ethyl acetate (300 mL) and washed sequentially with water (100 mL) and saturated saline (100 mL). The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated in vacuo to afford 7-amino-6-methoxy-2,3-dihydro-1H-inden-1-one (53b, 8.8 g, 100% yield) as a yellow solid. The product did not require further purification and could be used directly in the subsequent reaction.

[1] Patent: WO2009/62285, 2009, A1. Location in patent: Page/Page column 113
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[5] Patent: WO2009/62289, 2009, A1. Location in patent: Page/Page column 89-90