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• Synthesis

  Asymmetric Synthesis of (S)-1-(2-BROMOPHENYL)ETHANOL:

  

  Add 0.5 mmol of 1-(2-bromophenyl)ethanol to a test tube, add 1.5 mmol of dipropylene glycol dimethyl ether, purge with an oxygen bulb, and react at 120°C for 12 hours until the reaction is complete. Add 2.5 mmol of sodium formate to the reaction system, then add 0.0025 mmol of catalyst B, add 4 mL of methanol:water (3:1), and purge with nitrogen for 3 hours.

  The reaction was carried out at 50°C for 12 hours. After the reaction, the sample was washed with water, and the aqueous phase was extracted three times with ethyl acetate. The combined organic phases were concentrated to dryness and separated by column chromatography (petroleum ether: ethyl acetate = 10:1) to give (S)-1-(2-BROMOPHENYL)ETHANOL (67.3 mg), with a yield of 91% and an ee value of 88%.;

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