ChemicalBook CAS DataBase List 1144068-46-1

1144068-46-1

Name	N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
CAS	1144068-46-1
Molecular Formula	C27H33N7O4
MDL Number	MFCD22420813
Molecular Weight	519.595
MOL File	1144068-46-1.mol

Synonyms

WYE-132 WYE 125132 WYE 125132(WYE-132) WYE-132 (WYE-125132) WYE-125132;WYE 125132 WYE125132/WYE-125132/WYE-132 WYE-125132 (WYE-132);WYE-125132;WYE 125132; WYE125132 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-yl)-1H-pyrazolo[3,4-d 1-[4-(1-{1,4-dioxaspiro[4.5]decan-8-yl}-4-{8-oxa-3-azabicyclo[3.2.1]octan-3-yl}pyrazolo[3,4-d]pyrimidin-6-yl)phenyl]-3-methylurea N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl- 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-6-yl)phenyl)-3-Methylurea N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea USP/EP/BP WYE 125132 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE125132(WYE-132)

Chemical Properties

Melting point	162-184°C (dec.)
density	1.55
storage temp.	-20°C Freezer
solubility	DMSO (Slightly)
form	White powder solid.
pka	13.82±0.46(Predicted)
color	Off-White to Pale Beige
InChIKey	QLHHRYZMBGPBJG-UHFFFAOYSA-N
SMILES	N6(CC7OC(C6)CC7)c1nc(nc3[n](ncc31)C4CCC5(OCCO5)CC4)c2ccc(cc2)NC(=O)NC

Safety Data

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Hazard Information

Uses

WYE-125132 is a highly potent, ATP-competitive and specific mammalian target of rapamycin (mTOR) inhibitor.

Definition

ChEBI: 1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-pyrazolo[3,4-d]pyrimidinyl]phenyl]-3-methylurea is a member of ureas.

Biological Activity

A highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Shows an anti-proliferative activity against a variety of tumor cell lines. WYE-132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression.

in vivo

A single i.v. administration of 50 mg/kg WYE-132 (WYE-125132) into tumor-bearing mice leads to suppression of P-S6K(T389) and P-AKT(S473) for at least 8 hours in PC3MM2, MDA361, HCT116, and HT29 tumors, whereas the steady-state level of P-AKT(T308) is not significantly reduced, indicating that the antitumor efficacy of WYE-132 under such dosing regimens reflects the suppression of mTOR rather than PI3K. Oral administration of WYE-132 causes dose-dependent tumor growth delay in the PI3K/mTOR- and HER2-hyperactive MDA361 tumors with significant antitumor activity at 5 mg/kg, which correlates with a suppression P-S6 and P-AKT(S473) but not P-AKT(T308). An optimal dose of 50 mg/kg WYE-132 induces a substantial regression of large MDA361 tumors. WYE-132 also causes a potent and substantial tumor growth delay in the PTEN-null U87MG glioma^[1].

target

mTOR

IC 50

mTOR: 0.19 nM (IC₅₀); mTORC1; mTORC2; PI3Kα: 1.179 μM (IC₅₀); PI3Kδ: 2.38 μM (IC₅₀); hSMG1: 1.25 μM (IC₅₀)

storage

Store at -20°C

References

[1] yu k1, shi c, toral-barza l, lucas j, shor b, kim je, zhang wg, mahoney r, gaydos c, tardio l, kim sk, conant r, curran k, kaplan j, verheijen j, ayral-kaloustian s, mansour ts, abraham rt, zask a, gibbons jj. beyond rapalog therapy: preclinical pharmacology and antitumor activity of wye-125132, an atp-competitive and specific inhibitor of mtorc1 and mtorc2. cancer res. 2010 jan 15;70(2):621-31. doi: 10.1158/0008-5472.can-09-2340. epub 2010 jan 12.

Spectrum Detail

Supplier

Shanghai Boyle Chemical Co., Ltd.

Telephone

Websitehttp://www.boylechem.com

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

Jinan Trio PharmaTech Co., Ltd.

Telephone0531-88811783

Websitehttp://www.trio-pharmatech.com

ChemShuttle, Inc.

Telephone0510-83588313-811 18800520310

Websitehttps://www.jiehuapharma.com/

Haoyuan Chemexpress Co., Ltd.

Telephone021-58950125

Websitehttp://gb.chemexpress.com.cn

shanghai cooperpharm co.,LTD .

Telephone+86-021-58975553

Websitehttp://www.cooperpharm.com

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185 18149758185

Websitehttp://www.caerulumpharma.com

Bide Pharmatech Ltd.

Telephone400-400-164-7117 18317119277

Websitehttp://www.bidepharm.com

Suzhou yacoo science co.,Ltd

Telephone0512-87182056 18013166090

Websitehttp://www.yacoo.com.cn

AdooQ Bioscience CHINA

Telephone025-58849295

Websitehttp://www.adooq.cn

Credit Asia Chemical Co., Ltd.

Telephone+86 (21) 61124340

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16523/0_EN.htm

LETOPHARM LIMITED

Telephone+86-21-5821 5861

Websitehttp://www.letopharm.com

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

AN PharmaTech Co Ltd

Telephone86(21)68097365

Websitehttp://www.anpharma.net

Shanghai Synchem Pharma Co., ltd

Telephone21-619849051-1 18521059765

Websitehttp://www.synchem-pharma.com

SPIRO PHARMA

Telephone

Websitehttp://www.spiropharma.com.cn

Codow Chemical Co.,Ltd.

Telephone 18620099427

Websitehttp://www.howeipharm.com

1of4

Related Products

Send Inquriy