1135306-29-4

N⁶-benzoyl-Cyclic AMP (6-Bnz-cAMP) is a cell permeable cAMP analog that selectively activates PKA over exchange proteins activated by cAMP (Epac1 and 2, also known as RAPGEF3 and 4). It binds the AI and AII subunits of PKA with pK_i values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pK_i value of 1.3. 6-Bnz-cAMP stimulates the phosphorylation of the PKA substrate CREB but does not activate the Epac target Rap1. It can act synergistically with Epac-selective activators, such as 8-pCPT-2’-O-Me-cAMP .

N6-Benzoyladenosine 3’,5’-Cyclic Monophosphate Sodium Salt is a potent, cell-permeable PKA activator.

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