112714-99-5

Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC50 of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1[1].

[1] Lifang Wang, et al. Novel partially reversible NDM-1 inhibitors based on the naturally occurring houttuynin. Bioorg Chem. 2024 Apr 3:147:107328. DOI:10.1016/j.bioorg.2024.107328