1124382-72-4

The general procedure for the synthesis of 2-amino-8-bromo[1,2,4]triazolo[1,5-a]pyridine from compound (CAS:1124383-00-1) is as follows: 1. Dissolution step: Methanol (MeOH, 300 mL), hydroxylamine hydrochloride (62.83 g, 904 mmol) and diisopropylethylamine (DIPEA, 694 mL, 543 mmol) were added to a solution of Intermediate 50 (55 g, 181 mmol) in ethanol (EtOH, 300 mL). 2. Reaction step: the reaction mixture was stirred at room temperature (r.t.) for 6 hours. 3. Post-treatment step: the reaction mixture was concentrated in vacuum and the residue was suspended in diisopropyl ether (DIPE). 4. Separation step: the precipitate was collected by filtration. 5. 5. Yield: 51 37 g of intermediate were obtained in 96% yield.

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