111393-84-1

Name	Amitivir
CAS	111393-84-1
Molecular Formula	C3H2N4S
MDL Number	MFCD00866935
Molecular Weight	126.14
MOL File	111393-84-1.mol

Synonyms

Amitivir LY-217896 Cyanamide, N-1,3,4-thiadiazol-2-yl- Inhibitor,antiviral,thomyxovirus,inhibit,paramyxovirus CD-1,mice,Influenza Virus,Amitivir

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Chemical Properties

Boiling point	236.3±23.0 °C(Predicted)
density	1.613±0.06 g/cm3(Predicted)
pka	-0.94±0.10(Predicted)

Hazard Information

Uses

Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses. Amitivir is effective against influenza A and B viruses[1][2].

Definition

ChEBI: Amitivir is a secondary amine.

in vivo

Amitivir (LY 217896) (9 mg/m² of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus^[2].

References

[1] Hayden FG, et al. Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans. Antimicrob Agents Chemother. 1994;38(5):1178-1181. DOI:10.1128/AAC.38.5.1178
[2] Colacino JM, et al. Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt. Antimicrob Agents Chemother. 1990;34(11):2156-2163. DOI:10.1128/AAC.34.11.2156

Supplier

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Beijing Boorsen Biotechnology Co., Ltd

Telephone400-901-9800 18611424007

Websitehttp://www.bioss.com.cn/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

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