ChemicalBook CAS DataBase List 1110873-99-8

1110873-99-8

Name	RU-301
CAS	1110873-99-8
Molecular Formula	C21H19F3N4O4S
MDL Number	MFCD11802385
Molecular Weight	480.46
MOL File	1110873-99-8.mol

Chemical Properties

Boiling point	661.0±55.0 °C(Predicted)
density	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 250 mg/mL (520.33 mM)
form	Solid
pka	13.86±0.46(Predicted)
color	Light yellow to khaki

Hazard Information

Spectrum Detail

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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Animal Model:	NOD/SCIDγ mice (4-6 week; lung cancer xenograft model)^[1].
Dosage:	100, 300 mg/kg
Administration:	Intraperitoneal injection; single daily for 4 days
Result:	Significantly decreased tumor volume while body weights were not significantly different. Showed no notable toxicity but displayed good bioavailability with a t_1/2 life of ~7-8 hours.

Animal Model:	WT or Mertk^?/? male mice (fed NASH diet for 12 weeks)^[2].
Dosage:	300 mg/kg
Administration:	Intraperitoneal injection; 3 times a week for 4 weeks
Result:	Reduced liver fibrosis as indicated by decreases in liver picrosirius red staining and collagen gene expression.