11052-72-5

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F₁F_O-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.

Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors

Macrolide

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