11033-22-0

Coformycin is isolated from Nocardia interforma along with formycin. Coformycin shows a synergistic effect with formycin on Yoshida rat sarcoma cells because of its strong inhibition of adenosine deaminase, which inactivates formycin. Coformycin, having a characteristic seven-membered ring base moiety, is thought to be a typical example of a “transition-state analog” in the adenosine deaminase reaction. 2_x0002_-Deoxycoformycin (19b) has also been isolated also .

ChEBI: An N-glycosyl in which (8R)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol is attached to ribofuranose via a beta-N3-glycosidic bond. compound The parent of the class of coformycins.