Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant
protective effects in LPS-induced acute lung injury in mice[1][2].
References
[1] Liu M, et al. Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-κB axis in macrophages. Eur J Med Chem. 2023 Nov 15;260:115769. DOI:10.1016/j.ejmech.2023.115769 [2] Liang JY, et al. Two new antineoplastic diterpenes from Taxus mairei. Chem Pharm Bull (Tokyo). 1987 Jun;35(6):2613-4. DOI:10.1248/cpb.35.2613
