1101113-39-6

MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O₂^- to H₂O₂. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling.

MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2-to H2O2[1].

[1] Trnka J, et al. A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med. 2008;44(7):1406-1419. DOI:10.1016/j.freeradbiomed.2007.12.036